Tinnitus Drug Treatment Targets the Neurotransmitter of the Body

Published: 19th August 2010
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Tinnitus happens once excitatory neurotransmitters, especially glutamate, outweighs gamma-amino butyric acid (GABA) inhibitory neurotransmitters. The tinnitus drug treatment is composed of drugs that activate GABA inhibitory transmitters and that minimize the activity of glutamate.



There have been numbers of tinnitus drug treatment but almost all of them with weak results. Systemically weak and the complexity on the extent of tinnitus may be pointed out to its failures. For the previous years, drugs that functions in brain neurotransmitters such as glutamate which comprises these specific elements like acamprosate, memantine, flupirtine, gacyclidine and neramexane. GABA does also have its own composition most likely similar to glutamate. What usually contain in GABA are acamposate, clonazepam, alprazolam, and baclofen. Serotonin is also considered to be part of it especially on fluoxetine, acetylcholine and dopamine. All of these are added together and become the bulk of drug therapies for the problem.



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Some of the tinnitus drug treatment has been tested but some have failed. Some were found to have good results but the drug didnít last in the market. The acamprosate, though showing good results in 2005 trials, it wasnít followed up since the drug was phased out of the market by 2006. Three months of drug therapy using memantine showed poor results, and so with flupirtine. Neramexane and gacyclinide are potential drugs for the years to come. A certain pharmaceutical presented a case with results in Phase II experiment of neramexane in tinnitus last June in a certain meeting held in Sweden. This seems to be the first precise tinnitus drug treatment.

Operating with serotoninergic system could be beneficial in tinnitus treatment since serotonin has been related with hyperactivity. Blood levels were also discovered to be in an increased level in tinnitus patients. To some patients, the blockage of 5-HT receptors could be of help. In a study conducted, it showed the idea that electro physiological methods could give progress to rational tinnitus drug treatment.



A group of drugs which is called benzodiazepines, an anti-anxiety medication, is also used as a tinnitus drug treatment. This medication is prescribed for those patients with anxiety and pain disorders or other forms of anxiety. It has been said that benzodiazepines improves the activity of gama-amino butyric acid, an inhibitory neurotransmitters that relaxes and has a soothing effect on the brain. By improving the activity of GABA neurotransmitters, the drug diminishes fear, anxiety, emotional reactions and panic disorders. In a study conducted with 40 adult patients with tinnitus, it showed 76 percent of these patients had a significant result in the noise they notice. Although the drugís ability to minimize the symptoms of tinnitus is undetermined, it is pointed out that it is the drugís soothing effects and diminished the response of fear that enables the brain unaware of the perceived sounds within the human ear.



Bearing in mind that not only glutamate and GABA that are excitatory and inhibitory at auditory peripheral and central pathways but some neurotransmitters may also be excitatory or inhibitory depending on the part of the auditory pathways. So in conclusion,

tinnitus drug treatment should be given according on which neurotransmitters should be targeted on, case to case basis, patient per patient, and guided by the given methods that are yet to be established.



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